GlpBio

Progesterone Receptor

Progesterone Receptor(孕激素受体)

Progesterone receptor (PR) is a protein found inside cells, which is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two main forms, A and B, that differ in their molecular weight. Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration. After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins. Progesterone receptor plays a central role in diverse reproductive events associated with establishment and maintenance of pregnancy, alveolar development in the breast and sexual behavior.

Progesterone Receptor 相关产品(35)

  • GC50394 structure
    GC50394AG 205
    CAS: 442656-02-2
    纯度: >98.00%

    孕激素受体膜成分 1 (Pgrmc1) 配体

  • GC60815 structure
    GC60815Estradiol dipropionate
    CAS: 113-38-2
    纯度: >98.00%

    Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders.

  • GC61850 structure
    GC61850Medroxyprogesterone acetate D3
    纯度: >98.00%

    Medroxyprogesterone acetate D3 是 Medroxyprogesterone acetate 的氘代物。Medroxyprogesterone acetate 是一种广泛使用的合成类固醇，与孕酮 (progesterone)，雄激素 (androgen) 和糖皮质激素受体 (glucocorticoid receptors) 都有作用。

  • GC63143 structure
    GC63143PF-02413873
    CAS: 936345-35-6
    纯度: >99.00%

    PF-02413873 (PF-2413873) 是一种有效的、选择性、完全竞争性和口服活性的非甾体孕酮受体 (PR) 拮抗剂，Ki 值为 2.6 nM。PF-02413873 可以阻断孕激素结合和 PR 核易位，并在体内抑制子宫内膜的生长。

  • GC63706 structure
    GC63706Dydrogesterone-D6

    Dydrogesterone-D6 是 Dydrogesterone 的氘代物。Dydrogesterone 是口服活性的孕激素，可作用于孕酮缺乏相关疾病。

  • GC63751 structure
    GC63751Levonorgestrel-D8

    Levonorgestrel-D8 (D-Norgestrel-D8) 是 Levonorgestrel 的氘代物。Levonorgestrel是合成孕激素，可作用于孕酮受体。

  • GC63752 structure
    GC63752Norethindrone acetate-D8

    Norethindrone acetate-D8 (19-Norethindrone acetate-D8) 是 Norethindrone acetate 的氘代物。Norethindrone acetate 是一种雌性激素，可用于子宫内膜异位症研究。

  • GC68493 structure
    GC6849317α-Hydroxyprogesterone-d8
    CAS: 850023-80-2
    纯度: >99.00%

    17α-Hydroxyprogesterone-d8 是 17α-Hydroxyprogesterone 的氘代物。17α-Hydroxyprogesterone (17-Hydroxyprogesterone) 是一种内源性孕激素，在其他类固醇激素（包括糖皮质激素，雄激素，和雌激素）的生物合成中作为化学中间体。

  • GC70472 structure
    GC70472Promegestone
    CAS: 34184-77-5
    纯度: >98.00%

    Promegestone (R-5020)是一种黄体酮，是一种有效的黄体酮受体(PR)激动剂。

  • GC70603 structure
    GC70603PF-3882845
    CAS: 1023650-66-9
    纯度: >99.00%

    PF-3882845是一种非常高亲和力、选择性和口服有效的盐皮质激素受体（MR结合IC50=2.7 nM）拮抗剂，用于高血压和肾病。

  • GC71683 structure
    GC71683Chlormadinone acetate-d6-1
    纯度: >99.00%

    Chlormadinone acetate-d6-1是氘标记的醋酸氯地孕酮。