GlpBio

Eptifibatide Acetate

目录号: GC12447纯度: >99.50%同义词: 醋酸依替巴肽
A potent GPIIb/IIIa antagonist
Eptifibatide Acetate
Cas No.: 148031-34-9
规格价格库存数量操作
5mg¥372.00现货
1
10mg¥602.00现货
1
25mg¥1,260.00现货
1
50mg¥2,040.00现货
1
100mg¥3,270.00现货
1
10mM (in 1mL DMSO)¥552.00现货
1
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产品描述 Description

Eptifibatide is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity[1].

Eptifibatide is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity[1].

References:
[1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20.

实验参考方法 Experimental Reference Method

Cell experiment [1, 2]:

Cell lines

Activated platelets and leukocytes

Preparation method

The solubility of this compound in DMSO is >28.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.0625-1.5 w g/ml

Applications

Eptifibatide dose-dependently enhanced (0.0625-1.5 w g/ml) both collagen-induced platelet-monocyte (P/M) formation and monocyte TF expression with maximum enhancement about 60 and 120%, respectively, at 0.5 w g/ml eptifibatide. Eptifibatide had only a minor effect on platelet-neutrophil (P/N) formation and no effect on neutrophil TF expression. Eptifibatide dose-dependently reduced ADP, collagen, and thrombin-induced platelet aggregation (IC50 = 16-27 mg/mL), dense granule secretion (IC50 = 22-31 mg/mL) and lysosome secretion (IC50 = 25-50 mg/mL). Eptifibatide (8 mg/mL) together with bivalirudin (70 ng/mL, a direct thrombin inhibitor) effectively (approximately 90%) reduced platelet aggregation induced by thrombin (0.2 U/mL).

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Scholz T, Zhao L, Temmler U, et al. The GPIIb/IIIa antagonist eptifibatide markedly potentiates platelet-leukocyte interaction and tissue factor expression following platelet activation in whole blood in vitro[J]. Platelets, 2002, 13(7): 401-406.

[2]. Ciborowski M, Tomasiak M. The in vitro effect of eptifibatide, a glycoprotein IIb/IIIa antagonist, on various responses of porcine blood platelets[J]. Acta poloniae pharmaceutica, 2008, 66(3): 235-242.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
148031-34-9
同义词
醋酸依替巴肽
化学名
2-((3R,11S,17S,20S,25aS)-20-((1H-indol-3-yl)methyl)-3-carbamoyl-11-(4-((diaminomethylene)amino)butyl)-1,9,12,15,18,21-hexaoxodocosahydro-1H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl)acetic acid
SMILES
O=C([C@@](C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)([H])N([H])C([C@@](C([H])([H])C(O[H])=O)([H])N([H])C(C([H])([H])N([H])C3=O)=O)=O)N4[C@@](C(N([H])[C@@](C(N([H])[H])=O)([H])C([H])([H])SSC([H])([H])C([H])([H])C(N([H])[C@@]3([H])C([H])([H
分子式
C35H49N11O9S2
分子量
831.96 g/mol
溶解性
≥ 28.7mg/mL in DMSO
保存条件
-20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol