Dermorphin

目录号: GC31168纯度: >99.50%同义词: 皮啡肽

An opioid peptide

Cas No.: 77614-16-5

规格	价格	库存	数量
1mg	¥360.00	现货	1
5mg	¥720.00	现货	1
10mg	¥1,152.00	现货	1
25mg	¥1,843.00	现货	1
50mg	¥2,592.00	现货	1
10mm*1mlinwater	¥1,017.00	现货	1

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610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
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388(6745) (2025)
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387(6739) (2025)
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387(6734) (2025)
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产品描述 Description

Dermorphin is an opioid peptide originally isolated from the skin of South American frogs (Ph. sauvagei).¹ It binds to μ-opioid receptors (K_i = 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (K_i = 929 nM). In vivo, dermorphin (1.9 ?mol/kg, i.p.) inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats.² It inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons. Dermorphin (10-120 pmol/animal, i.c.v.) delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats.

1.Usenko, A.B., Emel'yanova, T.G., and MIasoedov, N.F.Dermorphins are natural opioids with an unique primary structure that determines their biological specificityBiol. Bull. Russ. Acad. Sci.29154-164(2002) 2.Melchiorri, P., and Negri, L.The dermorphin peptide familyGen. Pharmacol.27(7)1099-1107(1996)

实验参考方法 Experimental Reference Method

Kinase experiment:

Membrane protein (40 μg) is incubated in 0.5 mL volume of 50 mM Tris, 0.2 mM EGTA, 1 mM MgCl2, 100 mM NaCl, 0.1% BSA, 0.15 mM bacitracin; pH 7.4, GDP (33 μM), and ∼150 pM GTPγ[35S]. Varying concentrations of reference ligands (Dermorphin, N/OFQ, Dynorphin-A and Leu-enkephalin) or DeNo (1 pM-10 μM) is added prior to incubation. Non-specific binding is determined in the presence of unlabeled GTPγS (10 μM). Samples are incubated at 30°C for 1 h with gentle agitation. Reactions are terminated by vacuum filtration through dry Whatman GF/B filters, using a Brandel harvester[2].

References:

[1]. Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20.
[2]. Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号

77614-16-5

同义词

皮啡肽

SMILES

Tyr-{d-Ala}-Phe-Gly-Tyr-Pro-Ser-NH2

分子式

C₄₀H₅₀N₈O₁₀

分子量

802.87 g/mol

溶解性

H<sub>2</sub>O : 120 mg/mL (149.46 mM; Need ultrasonic)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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