Amifloxacin (Win49375) is a fluorinated quinolone-carboxylic acid antibacterial agent with activity against a broad range of gram-negative organisms. The MICs for 90% of isolates of representative urinary tract pathogens are 0.125μg/ml for Escherichia coli, 0.5μg/ml for Klebsiella pneumoniae, 1.0ug/ml for Proteus vulgaris, 0.5ug/ml for Citrobacter freundii, 2.0μg/ml for Pseudomonas aeruginosa, and 0.5ug/ml for Serratia marcescens [1].
Amifloxacin (Win49375), was an effective drug against experimental infections in mice when given parenterally. Amifloxacin (Win49375) was highly active by the oral route, with 50% effective doses within two- to three fold of those obtained with parenteral medication [2].
References:
[1]. Neu H C, Labthavikul P. Antibacterial activity of amifloxacin (WIN 49, 375), a new quinolone agent[J]. Diagnostic microbiology and infectious disease, 1985, 3(6): 469-478.
[2]. Cornett J B, Wagner R B, Dobson R A, et al. In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin)[J]. Antimicrobial agents and chemotherapy, 1985, 27(1): 4-10.
Amifloxacin (Win49375) 是一种氟化喹诺酮羧酸类抗菌剂，对多种革兰氏阴性菌具有活性。 90% 的代表性尿路病原体分离株的 MIC 为大肠杆菌 0.125μg/ml，肺炎克雷伯菌 0.5μg/ml，普通变形杆菌 1.0ug/ml，弗氏柠檬酸杆菌 0.5ug/ml，弗氏柠檬酸杆菌 2.0μg/ml铜绿假单胞菌和粘质沙雷氏菌 0.5ug/ml [1].
Amifloxacin (Win49375) 是一种有效的药物，当通过胃肠外给药时，它可以有效对抗小鼠的实验性感染。阿米沙星 (Win49375) 在口服途径中具有很高的活性，50% 的有效剂量是肠胃外用药的两到三倍[2]。