Adenosine amine congener (ADAC) is an adenosine A1 receptor agonist.1,2 It selectively binds adenosine A1 over A2A and A3 receptors (Kis = 0.85, 210, and 281 nM, respectively, for the rat receptors).3 ADAC (75 ?g/kg) increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of cerebral ischemia induced by bilateral carotid artery occlusion.1 It protects against auditory threshold shifts and inner and outer hair cell loss in rats following noise exposure at 110 dB when administered at a dose of 100 ?g/kg.2
1.Von Lubitz, D.K.J.E., Lin, R.C.-S., Bischofberger, N., et al.Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonistEur. J. Pharmacol.369(3)313-317(1999) 2.Vlajkovic, S.M., Lee, K.-H., Wong, A.C.Y., et al.Adenosine amine congener mitigates noise-induced cochlear injuryPurinergic Signal.6(2)273-281(2010) 3.Karl, M.O., Fleischhauer, J.C., Stamer, W.D., et al.Differential P1-purinergic modulation of human Schlemm’s canal inner-wall cellsAm. J. Physiol. Cell Physiol.288(4)C784-C794(2005)