GlpBio

A 1070722

目录号: GC10336纯度: >99.00%
A GSK3β inhibitor
A 1070722
Cas No.: 1384424-80-9
规格价格库存数量操作
1mg¥134.00现货
1
5mg¥333.00现货
1
10mg¥607.00现货
1
25mg¥1,193.00现货
1
50mg¥2,172.00现货
1
100mg¥3,162.00现货
1
10mM (in 1mL DMSO)¥266.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].

References:
[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1384424-80-9
化学名
(Z)-N'-(7-methoxyquinolin-4-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)carbamimidic acid
SMILES
COC1=CC2=NC=CC(/N=C(O)/NC3=CC=CC(C(F)(F)F)=N3)=C2C=C1
分子式
C17H13F3N4O2
分子量
362.31 g/mol
溶解性
<36.23mg/ml in DMSO
保存条件
Store at RT
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol