Vinclozolin is a dicarboximide fungicide. Metabolites of vinclozolin, M1 and M2 are effective antagonists of the androgen receptor in rats.1 Formulations containing vinclozolin have been used for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.2
1.Kelce, W.R., Monosson, E., Gamcsik, M.P., et al.Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolitesToxicol. Appl. Pharmacol.126(2)276-285(1994) 2.Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al.Biotransformation of vinclozolin by the fungus Cunninghemella elegansJ. Agric. Food Chem.48(12)6138-6148(2000)