3-Mercaptopropionic acid NHS ester is a linker of PROTACs and belongs to the alkyl/ether category [1]. PROTACs selectively degrade target proteins through the intracellular ubiquitin-proteasome system. The terminal N-hydroxysuccinimide (NHS) ester of 3-Mercaptopropionic acid NHS ester can react with amines, while the terminal thiol can react with thiol, alkene, and alkyn [2]. 3-Mercaptopropionic acid NHS ester can be used for the synthesis of PROTAC molecules [3].
References:
[1] An S, Fu L. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs[J]. EBioMedicine, 2018, 36: 553-562.
[2] Malone M R, Masson J F, Beaudoin S, et al. Novel surface coatings for antibody attachment to surface plasmon resonance sensors[C]. Smart Medical and Biomedical Sensor Technology III. SPIE, 2005, 6007: 36-45.
[3] Nhu C T, Dang P N, Thuy L H T, et al. An evaluation of a gold surface functionalization procedure for antibody binding and protein detection using 11-mercaptoundecanoic acid (11-MUA)[J]. Biomedical Engineering: Applications, Basis and Communications, 2024, 36(02): 2450002.
3-Mercaptopropionic acid NHS ester是一种PROTAC的linker，属于alkyl/ether类 [1]。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。3-Mercaptopropionic acid NHS ester的末端N-羟基琥珀酰亚胺（NHS）酯可以与胺反应，而末端硫醇可以与硫醇、烯烃和炔烃反应 [2]。3-Mercaptopropionic acid NHS ester可用于合成PROTAC分子 [3]。