1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, as a potent bioactive phospholipid, is a LPA receptor activator[1][2].
In vitro, 0.1 - 10 µM 1-Oleoyl-sn-glycero-3-phosphate elicits an acute rise of [Ca2+]i in rat and rabbit osteoclasts[1]. In addition, 1–5 μm 1-Oleoyl-sn-glycero-3-phosphate enhances osteoclast survival[1].
An ether-linked LPA (1-O-hexadecylglycerol 3-phosphate) has much decreased mitogenic activity as compared with the ester-linked analogue at concentrations less than 25 µM, and becomes cytotoxic at higher concentrations[2].
References:
[1] Lapierre DM, et al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010 Aug 13;285(33):25792-801.
[2] van Corven EJ, et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):163-9.
1-油酰基溶血磷脂酸（1-油酰基-sn-甘油-3-磷酸）钠作为一种有效的生物活性磷脂，是LPA受体激活剂[1][2]。
在体外，0.1-10 µM 1-油酰基-sn-甘油-3-磷酸引起大鼠和兔破骨细胞[Ca2+]i的急性升高[1]。此外，1-5 µM 1-油酰基-sn-甘油-3-磷酸可提高破骨细胞的存活率[1]。
在低于25 µM的浓度下，与酯连接的类似物相比，醚连接的LPA（1-O-十六烷基甘油3-磷酸）的促有丝分裂活性大大降低，并且在更高的浓度下变得具有细胞毒性[2]。