1,3-Distearoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 and sn-3 positions. It has been found in wheat bran extract.1 1,3-Distearoyl-rac-glycerol has been used in the synthesis of prodrug forms of the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen, naproxen , and diclofenac that have reduced ulcerogenicity.2,3,4
|1. Prinsen, P., GutiÉrrez, A., Faulds, C.B., et al. Comprehensive study of valuable lipophilic phytochemicals in wheat bran. J. Agric. Food Chem. 62(7), 1664-1673 (2014).|2. Khan, M.S., and Akhter, M. Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen. Eur. J. Med. Chem. 40(4), 371-376 (2005).|3. Redasani, V.K., and Bari, S.B. Synthesis and evaluation of glyceride prodrugs of naproxen. Open J. Med. Chem. 3(3), 87-92 (2013).|4. Khan, M.S.Y., and Akhter, M. Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac. Indian J. Exp. Biol. 42(11), 1066-1072 (2004).