GlpBio

VUF 10460

目录号: GC17585纯度: >98.00%
A histamine H4 receptor agonist
VUF 10460
Cas No.: 1028327-66-3
规格价格库存数量操作
1mg¥134.00现货
1
5mg¥503.00现货
1
10mg¥783.00现货
1
25mg¥1,328.00现货
1
50mg¥1,969.00现货
1
100mg¥2,869.00现货
1
10mM (in 1mL DMSO)¥397.00现货
1
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产品描述 Description

VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.

UF10460 binds to rat H3 and H4 receptor with pKi values of 5.75, and 7.46, respectively. VUF10460 displays approximately a 50-fold selectivity for the rat H4 receptor over the H3 receptor[1].

HCl-induced rat gastric lesions is significantly enhanced by the H4 receptor agonists VUF10460. This effect is not modified by H4 receptor antagonist JNJ7777120[1].

References:
[1]. Coruzzi G, et al. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669(1-3):121-7.

实验参考方法 Experimental Reference Method

Animal experiment:

Rats: VUF10460 is dissolved in 100% DMSO. Gastric lesions are induced in 24 h fasted rats by a single intragastric administration of 0.6 N HCl (5mL/kg volume). Drugs under study are administered subcutaneously 30 min before HCl. Rats are randomly divided to receive single doses (10 and/or 30 mg/kg) of immethridine, methimepip, immepip, VUF8430, VUF10460 or the vehicle, in a 1 mL/kg volume[1].

References:

[1]. Coruzzi G, et al. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur J Pharmacol. 2011 Nov 1;669(1-3):121-7.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1028327-66-3
化学名
4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2(1H)-imine
SMILES
CN1CCN(C(C=C(N2)C3=CC=CC=C3)=NC2=N)CC1
分子式
C15H19N5
分子量
269.34 g/mol
溶解性
DMSO: 100mg/mL
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol