VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM). VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM.
VEGFR-2-IN-39 (0-60 μM; 0-72 h) can efficiently reduce the protein levels of VEGFR-2 in a dose-dependent manner[1].
VEGFR-2-IN-39 (10-40 μM; 72 h) prolongs the S phase of the cell cycle in HUVECs[1].
VEGFR-2-IN-39 (0.1-40 μM; 72 h) induces apoptosis in HUVECs in a dose-dependent manner[1].