Vanucizumab is a first-in-class, bispecific IgG1-like monoclonal antibody that simultaneously blocks Showed tumor growth inhibition.
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[2]. Wolfgang Schaefer, et al. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11187-92.