Vamotinib

目录号: GC70110纯度: >98.00%同义词: PF-114
Vamotinib (PF-114) 是一种有效的,选择性具有口服活性的酪氨酸激酶抑制剂。Vamotinib 抑制 BCR/ABL 和 BCR/ABL-T315I 的自磷酸化。Vamotinib 诱导细胞凋亡 (apoptosis)。Vamotinib 显示出抗增殖和抗肿瘤活性。Vamotinib 在耐药性费城染色体阳性 (Ph+) 白血病的研究中具有潜力。

Vamotinib
Cas No.: 1416241-23-0
规格价格库存数量操作
1mg¥648.00现货
1
5mg¥1,602.00现货
1
10mg¥2,565.00现货
1
25mg¥5,130.00现货
1
10mM (in 1mL DMSO)¥3,483.00现货
1

文献被引

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产品描述 Description

Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces

[1]. Mian AA,et al. PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation. Leukemia. 2015 May;29(5):1104-14.
[2]. Ivanova ES, et al. PF?114, a novel selective inhibitor of BCR?ABL tyrosine kinase, is a potent inducer of apoptosis in chronic myelogenous leukemia cells. Int J Oncol. 2019 Jul;55(1):289-297.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1416241-23-0
同义词
PF-114
分子式
C29H27F3N6O
分子量
532.56 g/mol
溶解性
DMSO : 50 mg/mL (93.89 mM; Need ultrasonic)
保存条件
4°C, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol