GlpBio

UNC6934

目录号: GC64083纯度: >98.00%
UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
UNC6934
Cas No.: 2561494-77-5
规格价格库存数量操作
1mg¥864.00现货
1
5mg¥2,070.00现货
1
10mg¥3,240.00现货
1
25mg¥5,220.00现货
1
10mM (in 1mL DMSO)¥2,020.00现货
1
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文献被引

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产品描述 Description

UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.

UNC6934-mediated antagonism of PWWP1 leads to accumulation of endogenous NSD2 in the nucleolus. [1]

[1] Dilworth D, et al. Nat Chem Biol. 2022 Jan;18(1):56-63.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2561494-77-5
分子式
C24H21N5O4
分子量
443.45 g/mol
溶解性
DMSO : 25 mg/mL (56.38 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol