GlpBio

UCB9608

目录号: GC18164纯度: >99.00%同义词: (S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺
UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
UCB9608
Cas No.: 1616413-96-7
规格价格库存数量操作
1mg¥464.00现货
1
5mg¥1,067.00现货
1
10mg¥1,609.00现货
1
25mg¥3,162.00现货
1
50mg¥4,512.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

UCB9608 (UCB-9608) is a potent, selective, orally bioavailable PI4KIIIβ inhibitor with IC50 of 11 nM; also shows an IC50 of 37 nM in the human mixed lymphocyte reaction (HuMLR) assay, only inhibits the PI4KIIIβ and PI3KC2 α, β and γ lipid kinases in apnel of 250 kinases tested at 10 uM; UCB9608 is vastly more soluble, selective compound with improved metabolic stability and excellent pharmacokinetic profile, significantly prolongs allogeneic organ engraftment in vivo.

References:
1. Reuberson J, et al. J Med Chem. 2018 Jun 28. doi: 10.1021/acs.jmedchem.8b00521.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1616413-96-7
同义词
(S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺
化学名
(S)-4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide
SMILES
CN1N=CC2=C(N3[C@@H](C)CN(C(NC4=CC=C(OC)C=C4C)=O)CC3)N=C(N)N=C21
分子式
C20H26N8O2
分子量
410.482 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol