Trimethadione is an anticonvulsant.1,2 It decreases the levels of α-oxoglutarate, malate, and fumarate in the brain as well as plasma glucose levels in rats.1 Trimethadione increases latency to first pentetrazole-induced clonic seizure in mice (ED50 = 10 mg/kg).2 It also inhibits absence-like seizures but not tonic convulsions in spontaneously epileptic rats.3
1.Nahorski, S.R.Biochemical effects of the anticonvulsants trimethadione, ethosuximide and chlordiazepoxide in rat brainJ. Neurochem.19(8)1937-1946(1972) 2.Frey, H.H.Determination of the anticonvulsant potency of unmetabolized trimethadioneActa. Pharmacol. Toxicol. (Copenh)27(4)295-300(1969) 3.Sasa, M., Ohno, Y., Ujihara, H., et al.Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant ratEpilepsia29(5)505-513(1988)