Thioacetazone is an antitubercular agent.1 It is active against M. tuberculosis H37Rv, M. kansasii Bostrom, and M. avium serotype 2 (MICs = 0.3, 0.6, and 20 ?g/ml, respectively) but not M. simiae N29 or M. intracellulare serotype 16 (MICs = >40 ?g/ml for both). Formulations containing thioacetazone were previously used in the treatment of tuberculosis.
1.Collins, F.M., Klayman, D.L., and Morrison, N.E.Activity of 2-acetylpyridine and 2-acetylquinoline thiosemicarbazones tested in vitro in combination with other antituberculous drugsAm. Rev. Respir. Dis.125(1)58-60(1982)