GlpBio

SW2_152F

目录号: GC69980纯度: >99.00%
SW2_152F 是一种有效的选择性 chromobox 2 chromodomain (CBX2 ChD) 抑制剂，Kd 为 80 nM。SW2_152F 在体外对 CBX2 ChD 的选择性比其他 CBX paralogs 高 24-1000 倍。
SW2_152F
规格价格库存数量操作
5mg¥11,700.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro[1].

SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation[1].

[1]. Sijie Wang, et al. A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation. Chembiochem. 2021 Jul 1;22(13):2335-2344.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

分子式
C45H62Cl3N7O8
分子量
935.37 g/mol
溶解性
DMSO : 175 mg/mL (187.09 mM; Need ultrasonic)
保存条件
Store at -20°C, protect from light, stored under nitrogen
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol