GlpBio

SM-1295

目录号: GC63194纯度: >98.50%
SM-1295 是凋亡蛋白 IAP 的拮抗剂，其对 XIAP-BIR3、c-IAP1-BIR3 和 c-IAP2-BIR3 的 Kd 值分别为 3077 nM、3.2 nM 和 9.5 nM。
SM-1295
Cas No.: 1562375-46-5
规格价格库存数量操作
5 mg¥7,380.00现货
1
10 mg¥11,880.00现货
1
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产品描述 Description

SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].

SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of 900-fold for cIAP1 over XIAP[1].SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231[1].

[1]. Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.
[2]. Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62(12):5750-5772.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
1562375-46-5
分子式
C29H36BrN5O4
分子量
598.53 g/mol
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol