SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC50 value of 750 nM. SF-22 plays an important role in neurological disease.
References:
[1]. P Brothers, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screeningShaun. Mol Pharmacol. 2010 Jan;77(1):46-57.
















