关于 "Na+/K+ ATPase" 的结果23+ 个结果
- StrophanthidinCAS: 66-28-4
Strophanthidin 是一种天然的心脏糖苷。Strophanthidin 0.1 和 1 nmol/L 增加 Na+/K+-ATPase 活性，1~100 μ mol/L 抑制 Na+/K+-ATPase 活性，而 Strophanthidin 10 和 100 nmol/L 对 Na+/K+-ATPase活性无影响。Strophanthidin 增加舒张期和收缩期胞内 Ca2+ 浓度。
- Istaroxime hydrochlorideCAS: 374559-48-5
Istaroxime hydrochloride 是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌质/内质网钙 ATPase 2 (SERCA 2) 激活剂。
- Caloxin 2A1 TFA
Caloxin 2A1 TFA 是一种细胞外质膜 Ca2+-ATPase (PMCA) 肽抑制剂。Caloxin 2A1 TFA 不影响基础 Mg2+-ATPase 或 Na+-K+-ATPase。
- Chloroprocaine HClCAS: 3858-89-7
Chloroprocaine HCl (2-Chloroprocaine HCl) 是一种有效的 Na,K-ATPase 活性抑制剂，IC50 为 13 mM。
- GitoxinCAS: 4562-36-1
Gitoxin 是 Na+/K+-ATPase 的抑制剂，是Digitoxin 的降解代谢物，因ZOH 基团靠近C-17β 位置，可改善药代动力学和药效学数据。
- AcevaltrateCAS: 25161-41-5
Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.
- Lorcainide HClCAS: 58934-46-6
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na channel blocker. Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation. Acts at the ouabain binding site of guinea pig cardiac Na/K ATPase and inhibits the enzyme (IC50 = 34 μM).
- (R)-TegoprazanCAS: 942195-56-4
(R)-Tegoprazan ((R)-CJ-12420; example 3) 是一种苯并咪唑衍生物，是一种有效的胃 H+/K+-ATP 酶抑制剂，对犬肾 Na+/K+-ATPase 的 IC50 为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。
- Transdermal Peptide TFA
Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。
- C-Peptide 1 (rat)CAS: 41475-27-8
Studies of the cellular effects of C-peptide have shown that it binds specifically in a nanomolar concentration range to a G-protein coupled membrane receptor, with subsequent activation of Ca²?-dependent intracellular signaling pathways. This resulted in stimulation of both Na?-K?-ATPase, and endothelial nitric oxide synthase activities. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC18455 | Digoxigenin Monodigitoxoside | 5352-63-6 | Drug Metabolite | ||
A Na+/K+-ATPase inhibitor | |||||
| GC18474 | Acetyldigitoxin | 1111-39-3 | Heart Failure | ||
An Na+/K+ ATPase inhibitor | |||||
| GC18701 | Hellebrin | 13289-18-4 | Apoptosis | ||
An Na+/K+-ATPase inhibitor | |||||
| GC41485 | Digitoxigenin | 143-62-4 | Myocardial Contractility | ||
A Na+/K+ ATPase inhibitor | |||||
| GC49842 | Digoxigenin Bisdigitoxoside | 5297-05-2 | Apoptosis | ||
A Na+/K+-ATPase inhibitor | |||||
| GN10691 | Resibufogenin | 465-39-4 | Natural Products | ||
A Na+/K+-ATPase inhibitor | |||||
| GC18189 | Marinobufagenin | 470-42-8 | Na+/K+ ATPase | ||
An α1 Na+/K+ ATPase sodium pump inhibitor | |||||
| GC63832 | Strophanthidin | 66-28-4 | Na+/K+ ATPase | ||
Strophanthidin 是一种天然的心脏糖苷。Strophanthidin 0.1 和 1 nmol/L 增加 Na+/K+-ATPase 活性，1~100 μ mol/L 抑制 Na+/K+-ATPase 活性，而 Strophanthidin 10 和 100 nmol/L 对 Na+/K+-ATPase活性无影响。Strophanthidin 增加舒张期和收缩期胞内 Ca2+ 浓度。 | |||||
| GC11254 | Lithium carbonate | 554-13-2 | ATPase | ||
Na+/K+ ATPase pump inhibitor | |||||
| GN10365 | Bufalin | 465-21-4 | Na+/K+ ATPase | ||
Bufalin是一种Na+/K+-ATPase抑制剂（α1：Kd = 42.5nM；α2：Kd = 45nM；α3：Kd = 40nM）。 | |||||
| GC12413 | Rostafuroxin (PST 2238) | 156722-18-8 | Na+/K+ ATPase | ||
An endogenous ouabain blocker at the Na+/K+ ATPase | |||||
| GC10579 | Ouabain Octahydrate | 11018-89-6 | Autophagy | ||
Ouabain Octahydrate是一种Na+/K+-ATPase抑制剂，能够用于研究充血性心力衰竭。 | |||||
| GC17786 | Istaroxime hydrochloride | 374559-48-5 | Na+/K+ ATPase | ||
Istaroxime hydrochloride 是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌质/内质网钙 ATPase 2 (SERCA 2) 激活剂。 | |||||
| GC11448 | Istaroxime | 203737-93-3 | Na+/K+ ATPase | ||
Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase 抑制剂，IC50 为 0.11 μM。 | |||||
| GC62885 | Caloxin 2A1 TFA | - | Proton Pump | ||
Caloxin 2A1 TFA 是一种细胞外质膜 Ca2+-ATPase (PMCA) 肽抑制剂。Caloxin 2A1 TFA 不影响基础 Mg2+-ATPase 或 Na+-K+-ATPase。 | |||||
| GC17732 | Chloroprocaine HCl | 3858-89-7 | Others | ||
Chloroprocaine HCl (2-Chloroprocaine HCl) 是一种有效的 Na,K-ATPase 活性抑制剂，IC50 为 13 mM。 | |||||
| GC64887 | Gitoxin | 4562-36-1 | Na+/K+ ATPase | ||
Gitoxin 是 Na+/K+-ATPase 的抑制剂，是Digitoxin 的降解代谢物，因ZOH 基团靠近C-17β 位置，可改善药代动力学和药效学数据。 | |||||
| GC30927 | Acevaltrate | 25161-41-5 | Na+/K+ ATPase | ||
Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively. | |||||
| GB40264 | Lorcainide HCl | 58934-46-6 | - | ||
Lorcainide hydrochloride (58934-46-6) is a voltage-gated Na channel blocker. Protects murine cultured cortical neurons from injury induced by oxygen-glucose deprivation. Acts at the ouabain binding site of guinea pig cardiac Na/K ATPase and inhibits the enzyme (IC50 = 34 μM). | |||||
| GC76157 | Oxonol VI | 64724-75-0 | - | ||
Oxonol VI 可作为脂质囊泡中膜电位的光学指示剂。Oxonol VI 可用于检测与重组囊泡中 (Na+ + K+)-ATPase 活性相关的膜电位变化。 | |||||
| GC69839 | (R)-Tegoprazan | 942195-56-4 | Proton Pump | ||
(R)-Tegoprazan ((R)-CJ-12420; example 3) 是一种苯并咪唑衍生物，是一种有效的胃 H+/K+-ATP 酶抑制剂，对犬肾 Na+/K+-ATPase 的 IC50 为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。 | |||||
| GC38869 | Transdermal Peptide TFA | - | Na+/K+ ATPase | ||
Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。 | |||||
| GA21284 | C-Peptide 1 (rat) | 41475-27-8 | - | ||
Studies of the cellular effects of C-peptide have shown that it binds specifically in a nanomolar concentration range to a G-protein coupled membrane receptor, with subsequent activation of Ca²?-dependent intracellular signaling pathways. This resulted in stimulation of both Na?-K?-ATPase, and endothelial nitric oxide synthase activities. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover. | |||||