GlpBio

Resibufogenin

目录号: GN10691纯度: >98.00%同义词: 酯蟾毒配基; Bufogenin; Recibufogenin
A Na+/K+-ATPase inhibitor
Resibufogenin
Cas No.: 465-39-4
规格价格库存数量操作
20mg¥1,145.00现货
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产品描述 Description

Resibufogenin, a component of huachansu, has been shown to exhibit the anti-proliferative effect against cancer cells, and this may be attributed to the degradation of cyclin D1 caused by the activation of GSK-3β.IC50 Value:Target:In vitro: The effects of Resibufogenin on the outward delayed rectifier potassium current (IK) and outward transient potassium current (IA) in rat hippocampal neurons was investigated, and it inhibited both IK and IA, at 1 μM concentration RBG could alter some channel kinetics and gating properties of IK, such as steady-state activation and inactivation curves, open probability and time constants [1].In vivo: Resibufogenin prevented evidence of oxidative stress in "preeclamptic" rats [2].

References:
[1]. Hao S, et al. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53.
[2]. Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8.
[3]. Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851.
[4]. Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6.
[5]. Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4.
[6]. Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
465-39-4
同义词
酯蟾毒配基; Bufogenin; Recibufogenin
化学名
5-((1R,2aR,3aS,5aR,7S,9aS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one
SMILES
O=C1OC([H])=C(C([H])=C1[H])[C@]2([H])[C@](C([H])([H])C3([H])[H])(C([H])([H])[H])[C@]4(C5([H])C3([H])[C@](C([H])([H])C([H])([H])[C@]6([H])O[H])(C([H])([H])[H])[C@](C6([H])[H])([H])C([H])([H])C5([H])[H])O[C@]4([H])C2([H])[H]
分子式
C24H32O4
分子量
384.51 g/mol
溶解性
≥ 14.5mg/mL in DMSO
保存条件
Store at 2-8°C,protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol