U 73343 is an inactive analogue of U 73122. U 73122 is a widely used inhibitor of receptor-mediated phospholipase C (PLC), which inhibits the role of PLC in endothelin-1 (ET-1) and parathyroid hormone (PTH)-induced calcium transients. U 73343 is inactive and is often used as a negative control for U 73122[1][2].
References:
[1] Muto Y, Nagao T, Urushidani T. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997;282(3):1379-1388.
[2] Tatrai A, Lee SK, Stern PH. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim Biophys Acta. 1994;1224(3):575-582.
U 73343是U 73122的非活性类似物。U 73122是一种常用的受体介导型磷脂酶C（PLC）的抑制剂，能抑制PLC在内皮素-1（ET-1）和甲状旁腺激素（PTH）引发的钙瞬变中起的作用。U 73343无活性，常作为U 73122的阴性对照药物使用[1][2]。