GlpBio

Hellebrin

目录号: GC18701纯度: >99.00%同义词: 蒜蘆黎素
An Na+/K+-ATPase inhibitor
Hellebrin
Cas No.: 13289-18-4
规格价格库存数量操作
1mg¥878.00现货
1
5mg¥3,681.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides. Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides. This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
13289-18-4
同义词
蒜蘆黎素
化学名
3β-[(6-deoxy-4-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-5β,14-dihydroxy-19-oxo-bufa-20,22-dienolide
SMILES
O=C(C=C1)OC=C1[C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5(O)C[C@@H](O[C@@]6([H])[C@@H]([C@@H]([C@@]([C@H](C)O6)([H])O[C@H]7[C@@H]([C@H]([C@@H]([C@@H](CO)O7)O)O)O)O)O)CC[C@]5(C=O)[C@@]4([H])CC[C@]23C
分子式
C36H52O15
分子量
724.8 g/mol
溶解性
Water: 4 mg/ml
保存条件
Store at -20°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol