关于 "ROS" 的结果10+ 个结果
- Alectinib HydrochlorideCAS: 1256589-74-8
Alectinib Hydrochloride是一种强效、选择性、可口服的ALK抑制剂，IC 50 值为1.9nM，K d 值为2.4nM。
- EnsulizoleCAS: 27503-81-7
Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.
- (E/Z)-BCICAS: 15982-84-0
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
- AdaphostinCAS: 241127-58-2
Adaphostin (NSC 680410) 是 AG957 的金刚烷基酯，是一种有效的 p210bcr/abl 抑制剂 (IC50=14 μM)。 Adaphostin 在人 T 淋巴细胞白血病细胞系中诱导细胞凋亡（IC50 范围为 17 至 216 nM）。 Adaphostin 对慢性和急性髓性白血病细胞具有显着的选择性活性。 Adaphostin 增加了 CLL B 细胞内的活性氧 (ROS) 水平。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC17622 | Ro 08-2750 | 37854-59-4 | Others | ||
Ro 08-2750是一种竞争性Musashi (MSI)-RNA相互作用抑制剂，IC50值为2.7±0.4µM。 | |||||
| GC19154 | Roblitinib | 1708971-55-4 | FGFR | ||
Roblitinib (FGF-401) 是一种 1,8-naphthyridine 吡啶衍生物。 | |||||
| GC15466 | RO9021 | 1446790-62-0 | Spleen Tyrosine Kinase (Syk) | ||
RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂，平均 IC50 为 5.6 nM。 | |||||
| GC14695 | CO-1686 (AVL-301) | 1374640-70-6 | EGFR | ||
A selective inhibitor of mutant EGFR | |||||
| GC16025 | CH5424802 | 1256580-46-7 | ALK | ||
An orally available inhibitor of ALK | |||||
| GC35280 | Alectinib Hydrochloride | 1256589-74-8 | ALK | ||
Alectinib Hydrochloride是一种强效、选择性、可口服的ALK抑制剂，IC50值为1.9nM，Kd值为2.4nM。 | |||||
| GC74484 | Imgatuzumab | 959963-46-3 | EGFR | ||
Imgatuzumab (RG 7160)是一种抗EGFR的人源化单克隆抗体。 | |||||
| GC38776 | Ensulizole | 27503-81-7 | ROS | ||
Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation. | |||||
| GC25000 | (E/Z)-BCI | 15982-84-0 | ROS | ||
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | |||||
| GC15579 | Adaphostin | 241127-58-2 | Bcr-Abl | ||
Adaphostin (NSC 680410) 是 AG957 的金刚烷基酯，是一种有效的 p210bcr/abl 抑制剂 (IC50=14 μM)。 Adaphostin 在人 T 淋巴细胞白血病细胞系中诱导细胞凋亡（IC50 范围为 17 至 216 nM）。 Adaphostin 对慢性和急性髓性白血病细胞具有显着的选择性活性。 Adaphostin 增加了 CLL B 细胞内的活性氧 (ROS) 水平。 | |||||