Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.
Ensulizole selectively inhibits activity of HDAC3.[2]
[1] Wael H M Abdelraheem, et al. J Hazard Mater. 2015 Jan 23;282:233-40. [2] Hsu CW, et al. J Biomol Screen. 2016 Jul;21(6):643-52.
















