关于 "nAChR" 的结果12 个结果
筛选:Signaling Pathways×
- 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneCAS: 64091-91-4
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC 50 值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC 50 值为0.005μM。
- TMB 8 (hydrochloride)CAS: 53464-72-5
A non-competitive antagonist of nAChRs and an inhibitor of intracellular calcium availability
- α-Conotoxin AuIB (trifluoroacetate salt)
A conotoxin and an antagonist of α3β4 subunit-containing nAChRs
- Simufilam hydrochlorideCAS: 2480226-07-9
Simufilam (PTI-125) (hydrochloride) 是一种低毒的，具有口服活性的 filamin A (FLNA) 激活剂。Simufilam (hydrochloride) 可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam (hydrochloride) 可用于阿尔茨海默症的研究。
- α-Conotoxin PnIA (trifluoroacetate salt)
A peptide antagonist of α3β2-subunit containing and α7 nAChRs
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GP10010 | COG 133 | 514200-66-9 | Alzheimer | ||
A peptide fragment of ApoE and an α7 nAChR antagonist | |||||
| GC45196 | α-Bungarotoxin (trifluoroacetate salt) | - | Toxins | ||
A neurotoxin that blocks nAChR | |||||
| GC41676 | (±)-Nornicotine | 5746-86-1 | ECM & Adhesion Molecules | ||
An active metabolite of nicotine and nAChR agonist | |||||
| GC46607 | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone | 64091-91-4 | DNA/RNA Methylation | ||
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC50值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC50值为0.005μM。 | |||||
| GC47869 | Pancuronium (bromide hydrate) | - | Neuroscience | ||
An antagonist of muscle-type nAChRs | |||||
| GC19438 | TMB 8 (hydrochloride) | 53464-72-5 | Neuroscience | ||
A non-competitive antagonist of nAChRs and an inhibitor of intracellular calcium availability | |||||
| GC43383 | DBO-83 | 195211-53-1 | Behavioral Neuroscience | ||
An agonist of nAChRs | |||||
| GC49097 | α-Conotoxin AuIB (trifluoroacetate salt) | - | Toxins | ||
A conotoxin and an antagonist of α3β4 subunit-containing nAChRs | |||||
| GC49140 | α-Conotoxin ImI (trifluoroacetate salt) | - | Toxins | ||
A conotoxin and an antagonist of α7 nAChRs | |||||
| GC63192 | Simufilam | 1224591-33-6 | Others | ||
Simufilam(PTI-125) is potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR. | |||||
| GC63193 | Simufilam hydrochloride | 2480226-07-9 | Others | ||
Simufilam (PTI-125) (hydrochloride) 是一种低毒的，具有口服活性的 filamin A (FLNA) 激活剂。Simufilam (hydrochloride) 可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam (hydrochloride) 可用于阿尔茨海默症的研究。 | |||||
| GC52338 | α-Conotoxin PnIA (trifluoroacetate salt) | - | Cancer Biology | ||
A peptide antagonist of α3β2-subunit containing and α7 nAChRs | |||||