α-Conotoxin PnIA is a peptide originally isolated from the venom of the marine mollusk C. pennaceus and an antagonist of α3β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) and α7 nAChRs (IC50s = 7.9 and 62.7 nM, respectively).1,2 α-Conotoxin PnIA (0.1 nmol/kg) in combination with baicalein inhibits tumor growth and increases survival in an Ehrlich murine spontaneous adenocarcinoma model.3
1.Fainzilber, M., Hasson, A., Oren, R., et al.New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptorsBiochemistry33(32)9523-9529(1994) 2.Hopping, G., A., W.C.-I., Hogg, R.C., et al.Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptorsBiochem. Pharmacol.91(4)534-542(2014) 3.Osipov, A.V., Terpinskaya, T.I., Yanchanka, T., et al.α-Conotoxins enhance both the in vivo suppression of Ehrlich carcinoma growth and in vitro reduction in cell viability elicited by cyclooxygenase and lipoxygenase inhibitorsMar. Drugs18(4)193(2020)