关于 "c-RET" 的结果36 个结果

The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.

The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.

Precursor of the secreted amyloid β-protein (1-40) and (1-42). The identification of amyloid-β-protein (1-46) led to the identification of a zeta-cleavage site between the known γ- and ε-cleavage sites within the transmembrane domain of amyloid-β precursor protein (APP).

Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.

Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min?¹.

An incretin hormone

Cleavage of APP by alpha- and gamma secretase (i.

The insulinotropic peptide encoded by nucleobindin 1 upregulated preproinsulin mRNA expression and insulin secretion.

Oxyntomodulin potently inhibits gastric acid secretion and pancreatic enzyme secretion when infused iv.

Glucagon-like peptide 1 (GLP-1) (1-32) is an endogenous incretin hormone.

Glucose-dependent Insulinotropic Polypeptide (GIP) (1-39) is an endogenous 39-amino acid peptide hormone that induces insulin secretion.

Gastric inhibitory peptide 1 (GIP-1) (3-42) is a peptide fragment of the incretin hormone GIP and a GIP receptor antagonist.