Gastric inhibitory peptide 1 (GIP-1) (3-42) is a peptide fragment of the incretin hormone GIP and a GIP receptor antagonist.[1] It is formed from GIP by serum dipeptidyl peptidase 4 (DDP-4). GIP-1 (3-42) (100 nM) reduces insulin secretion from BRIN-BD11 pancreatic cells. It increases plasma glucose levels and decreases plasma insulin levels in an ob/ob mouse model of diabetes when administered at a dose of 25 nmol/kg.
References:
[1].Gault, V.A., Parker, J.C., Harriott, P., et al.Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivoJ. Endocrinol.175(2)525-533(2002).