关于 "nAChR" 的结果9 个结果
- 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneCAS: 64091-91-4
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC 50 值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC 50 值为0.005μM。
- (Rac)-ABT-202 dihydrochlorideCAS: 1258641-38-1
(Rac)-ABT-202 dihydrochloride 是 ABT-202 的外消旋体。ABT-202 是一种烟碱乙酰胆碱受体 (nAChRs) 的激动剂，可以用作止痛药。
Others - Acetylthiocholine (iodide)CAS: 1866-15-5
A substrate for AChE and an agonist of α4β2-subunit containing nAChRs
- Simufilam hydrochlorideCAS: 2480226-07-9
Simufilam (PTI-125) (hydrochloride) 是一种低毒的，具有口服活性的 filamin A (FLNA) 激活剂。Simufilam (hydrochloride) 可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam (hydrochloride) 可用于阿尔茨海默症的研究。
Others - Simufilam dihydrochlorideCAS: 2480226-06-8
Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC12283 | Nicotine Difartrate | 65-31-6 | Others | ||
Nicotinic acetylcholine receptor (nAChR) agonist | |||||
| GC45196 | α-Bungarotoxin (trifluoroacetate salt) | - | Toxins | ||
A neurotoxin that blocks nAChR | |||||
| GC46607 | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone | 64091-91-4 | DNA/RNA Methylation | ||
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone是一种主要存在于烟草制品中的强效烟草特异性致癌物，对α7烟碱型乙酰胆碱受体（α7 nAChR）具有很高的亲和力，在小细胞肺癌（SCLCs）中的EC50值为0.03μM，在肺神经内分泌细胞（PNECs）中的EC50值为0.005μM。 | |||||
| GC38875 | (Rac)-ABT-202 dihydrochloride | 1258641-38-1 | Others | ||
(Rac)-ABT-202 dihydrochloride 是 ABT-202 的外消旋体。ABT-202 是一种烟碱乙酰胆碱受体 (nAChRs) 的激动剂，可以用作止痛药。 | |||||
| GC49140 | α-Conotoxin ImI (trifluoroacetate salt) | - | Toxins | ||
A conotoxin and an antagonist of α7 nAChRs | |||||
| GC49224 | Acetylthiocholine (iodide) | 1866-15-5 | Environmental Toxicology | ||
A substrate for AChE and an agonist of α4β2-subunit containing nAChRs | |||||
| GC63192 | Simufilam | 1224591-33-6 | Others | ||
Simufilam(PTI-125) is potent, orally active small drug against AD, which interacts to filamin and controls the actin cytoskeleton. Simufilam reduces tau hyperphosphorylation, amyloid and tau formation by preventing and reversing the binding of Aβ42 to α7nAChR. | |||||
| GC63193 | Simufilam hydrochloride | 2480226-07-9 | Others | ||
Simufilam (PTI-125) (hydrochloride) 是一种低毒的，具有口服活性的 filamin A (FLNA) 激活剂。Simufilam (hydrochloride) 可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam (hydrochloride) 可用于阿尔茨海默症的研究。 | |||||
| GC25935 | Simufilam dihydrochloride | 2480226-06-8 | Actin | ||
Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies. | |||||