Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
[1] Hoau-Yan Wang, et al. Neurobiol Aging. 2017 Jul;55:99-114.
















