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关于 "Topoisomerase" 的结果54+ 个结果

筛选:DNA Damage/DNA Repair×
  • GC39425 structure
    GC39425
    Proscillaridin A
    CAS: 466-06-8

    Proscillaridin A 是强力的拓扑异构酶 I 和 II topoisomerase I/II 抑制剂，抑制拓扑异构酶 I 和 II 的 IC50 值分别为 30 nM 和 100 nM。

    Topoisomerase
  • GC60107 structure
    GC60107
    Chloroquinoxaline sulfonamide
    CAS: 97919-22-7

    Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物，是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽，兔，绵羊和牛的球虫病。 具有抗肿瘤活性。

    Parasite
  • GC60374 structure
    GC60374
    Trovafloxacin
    CAS: 147059-72-1

    A topoisomerase IV and DNA gyrase inhibitor

    Bacterial
  • GC60669 structure
    GC60669
    Camptothecin-20(S)-O-propionate
    CAS: 194414-69-2

    Camptothecin-20(S)-O-propionate(CZ48)是喜树碱(CPT)的类似物，是强效的抗肿瘤化合物。Camptothecin-20(S)-O-propionate(CZ48)是拓扑异构酶I(topoisomerase-Ι)的抑制剂。

    Topoisomerase
  • GC60692 structure
    GC60692
    CH-0793076 TFA

    CH-0793076(TP3076)TFA，喜树碱的六环类似物，是TP300的活性药物和主要代谢物。CH-0793076TFA抑制DNA拓扑异构酶I(DNAtopoisomeraseI)，IC50为2.3μM。CH-0793076TFA对表达BCRP(乳腺癌耐药蛋白)的细胞也有活性。

    Topoisomerase
  • GC60826 structure
    GC60826
    Etoposide phosphate
    CAS: 117091-64-2

    Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。

    Autophagy
  • GC60873 structure
    GC60873
    Gimatecan
    CAS: 292618-32-7

    Gimatecan(ST1481)是一种有效的拓扑异构酶I(topoisomeraseI)抑制剂。Gimatecan是一种具有口服活性的喜树碱类似物。具有抗肿瘤活性。

    Topoisomerase
  • GC61224 structure
    GC61224
    Pyrazoloacridine
    CAS: 99009-20-8

    Pyrazoloacridine(NSC366140)具有抗癌活性，抑制拓扑异构酶1和2的活性(topoisomerases1and2)。Pyrazoloacridine(NSC366140)对K562髓系白血病细胞中的IC50值为1.25μM(24h)。

    Apoptosis
  • GC46880 structure
    GC46880
    ARN24139
    CAS: 2699768-78-8

    A topoisomerase II poison

    Topoisomerase
  • GC18751 structure
    GC18751
    Reticulol
    CAS: 26246-41-3

    A cAMP phosphodiesterase and DNA topoisomerase I inhibitor

    Topoisomerase
  • GC19148 structure
    GC19148
    Exatecan Mesylate
    CAS: 169869-90-3

    A DNA topoisomerase I inhibitor

    Topoisomerase
  • GC19342 structure
    GC19342
    SW044248
    CAS: 522650-83-5

    A DNA topoisomerase I inhibitor

    Topoisomerase
  • GC38194 structure
    GC38194
    (±)-10-Hydroxycamptothecin
    CAS: 64439-81-2

    Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.

    Topoisomerase
  • GC38511 structure
    GC38511
    Groenlandicine
    CAS: 38691-95-1

    Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。

    Topoisomerase
  • GC38774 structure
    GC38774
    DRF-1042
    CAS: 200619-13-2

    DRF-1042 是一种具有口服活性的喜树碱类似物，具有抑制 DNA 拓扑异构酶 I (DNA topoisomerase I) 的作用。DRF-1042 对一组人癌细胞株，包括多药耐药 (MDR)表型，显示出良好的抗癌活性。

    ADC Cytotoxin
  • GC46113 structure
    GC46113
    CAY10744
    CAS: 2375613-31-1

    A topoisomerase II-α poison

    Apoptosis
  • GC50105 structure
    GC50105
    CKD 602

    Topoisomerase I inhibitor

    Topoisomerase
  • GC37571 structure
    GC37571
    Rubitecan
    CAS: 91421-42-0

    A DNA topoisomerase I inhibitor

    Topoisomerase
  • GC42783 structure
    GC42783
    Ametantrone
    CAS: 64862-96-0

    An inhibitor of topoisomerase II

    Topoisomerase
  • GC32822 structure
    GC32822
    TAS-103 dihydrochloride (BMS-247615 dihydrochloride)
    CAS: 174634-09-4

    A DNA topoisomerase I and II inhibitor

    Topoisomerase
  • GC33066 structure
    GC33066
    Belotecan hydrochloride (CKD-602)
    CAS: 213819-48-8

    A DNA topoisomerase I inhibitor

    Topoisomerase
  • GC33108 structure
    GC33108
    Exatecan (DX-8951)
    CAS: 171335-80-1

    Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition.

    Topoisomerase
  • GC61844 structure
    GC61844
    Merbarone
    CAS: 97534-21-9

    Merbarone (NSC 336628) 是一种具有口服活性的拓扑异构酶 II (topoisomerase II) 抑制剂。Merbarone 的主要作用是阻断拓扑异构酶 II 介导的 DNA 切割，而不会稳定拓扑 II-DNA 共价复合物。Merbarone 具有抗肿瘤功效。

    Topoisomerase
  • GC61965 structure
    GC61965
    Coralyne chloride
    CAS: 38989-38-7

    Coralyne chloride 是一种具有强抗癌活性的原小檗碱化合物。Coralyne chloride 可以作为一种有效的拓扑异构酶 I (topoisomerase I) 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。Coralyne chloride 可用于制备 Coralyne 衍生物，并可以用作 DNA 结合荧光探针制备。

    Topoisomerase