Rifamycin SV is a broad-spectrum antibiotic that inhibits bacterial DNA-dependent RNA polymerase.1,2 It is effective against Gram-positive bacteria but only moderately active against Gram-negative bacteria.1,2
1.Riva, S., and Silvestri, L.G.Rifamycins: A general viewAnnu. Rev. Microbiol.26199-224(1982) 2.Kohanski, M.A., Dwyer, D.J., and Collins, J.J.How antibiotics kill bacteria: From targets to networksNat. Rev. Microbiol.8(6)423-435(2010)