GlpBio

DYRK

DYRK(双特异性酪氨酸磷酸化调节激酶)

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

DYRK 相关产品(33)

  • GC70625 structure
    GC70625AnnH31
    CAS: 241809-12-1
    纯度: >99.00%

    AnnH31是Dyrk1A抑制剂（IC50:81nM）。

  • GC70985 structure
    GC70985Dyrk1A-IN-3
    CAS: 2493976-27-3
    纯度: >99.00%

    Dyrk1A-IN-3（化合物8b）是一种高度选择性的双特异性酪氨酸调节激酶1A（DYRK1A）抑制剂，保持高水平的DYRK1A结合亲和力（IC50=76 nM）。

  • GC71197 structure
    GC71197FINDY
    CAS: 1507367-37-4
    纯度: 不显示

    FINDY是DYRK1A的折叠中选择性抑制剂。

  • GC72931 structure
    GC72931HTH-01-091 TFA
    纯度: >98.00%

    HTH-01-091 TFA是一种有效的、选择性的母胚亮氨酸拉链激酶（MELK）抑制剂，IC50为10.5 nM。

  • GC72982 structure
    GC72982BT173
    CAS: 2232180-74-2
    纯度: >98.00%

    BT173是一种强效的同源结构域相互作用蛋白激酶2（HIPK2）抑制剂。

  • GC73224 structure
    GC73224CLK1-IN-3
    CAS: 2922550-28-3
    纯度: >98.00%

    CLK1-IN-3（化合物10ad）是一种有效的选择性Clk1抑制剂，IC50为5 nM，对Dyrk1A的选择性超过300倍。

  • GC73707 structure
    GC73707ON 108600
    CAS: 1585246-23-6
    纯度: >99.00%

    ON 108600是CK2（酪蛋白激酶2）/TNIK/DYRK1的抑制剂，DYRK1A/DYRKB、DYRK2、CK2α1/CK2α2和TNIK的IC50分别为0.016μm/0.007μm、0.028μm、0.05μm/0.005μm和0.005μm。

  • GC74165 structure
    GC741654-(Trifluoromethyl)aniline-d4
    CAS: 1219795-48-8
    纯度: >99.00%

    4-(Trifluoromethyl)aniline-d4是氘标记的4-三氟甲基苯胺。

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    纯度: >98.00%

    (R)-(+)-O-Demethylbuchenavianine是细胞周期蛋白依赖性激酶CDK的抑制剂。