GlpBio

Gamma Secretase

Gamma Secretase(伽玛分泌酶)

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

Gamma Secretase 相关产品(42)

  • GC62998 structure
    GC62998GSM-1
    CAS: 884600-68-4
    纯度: >98.00%

    GSM-1 是有效的 γ-secretase 调节剂。GSM-1 直接靶向早衰蛋白 1 (PS1) 的跨膜结构域。

  • GC63366 structure
    GC63366Fosciclopirox
    CAS: 1380539-06-9

    Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies.

  • GC63407 structure
    GC63407PF-06648671
    CAS: 1587727-31-8
    纯度: >98.00%

    PF-06648671 是一种新型的，可通透血脑屏障的，具有口服活性的 γ 分泌酶 (γ‐Secretase) 调节剂 (GSM)。PF-06648671 减少 Aβ42 和 Aβ40，并且伴随 Aβ37 和 Aβ38 的增加。PF-06648671 用于阿尔茨海默病的研究。

  • GC67476 structure
    GC67476(E/Z)-Sulindac sulfide
    CAS: 32004-67-4

    (E/Z)-Sulindac sulfide 是一种有效的 γ-secretase 调节剂。(E/Z)-Sulindac sulfide 可选择性地减少 Aβ42 产生，有利于更短的 Aβ 类型的产生。(E/Z)-Sulindac sulfide 可用于阿尔兹海默症的研究。

  • GC15899 structure
    GC15899MK-0752
    CAS: 471905-41-6
    纯度: >98.00%

    A potent inhibitor of γ-secretase

  • GC17671 structure
    GC17671YO-01027 (Dibenzazepine, DBZ)
    CAS: 209984-56-5
    纯度: >98.00%

    YO-01027 (Dibenzazepine, DBZ)是一种γ-分泌酶抑制剂，对APP裂解和Notch裂解的IC 50 值分别为2.64±0.30nM和2.92±0.22nM。

  • GC12191 structure
    GC12191LY-411575
    CAS: 209984-57-6
    纯度: >98.00%

    A γ-secretase inhibitor

  • GC17791 structure
    GC17791LY2811376
    CAS: 1194044-20-6
    纯度: >99.50%

    A BACE1 inhibitor

  • GC10064 structure
    GC10064Flurizan
    CAS: 51543-40-9
    纯度: >99.50%

    A COX-inactive enantiomer of flurbiprofen

  • GC16431 structure
    GC16431MRK 560
    CAS: 677772-84-8
    纯度: >99.00%

    A potent inhibitor of γ-secretase

  • GC12659 structure
    GC12659Begacestat
    CAS: 769169-27-9
    纯度: >99.50%

    An inhibitor of γ-secretase

  • GC15364 structure
    GC15364L-685,458
    CAS: 292632-98-5
    纯度: >99.00%

    A γ-secretase inhibitor

  • GC16434 structure
    GC16434TC-E 5006
    CAS: 1257395-14-4

    γ-secretase modulator

  • GC12653 structure
    GC12653LY3039478
    CAS: 1421438-81-4
    纯度: >98.00%

    A Notch inhibitor

  • GC13619 structure
    GC13619JLK 6
    CAS: 62252-26-0

    A protease inhibitor

  • GC10998 structure
    GC10998PF-03084014
    CAS: 865773-15-5

    γ-secretase inhibitor

  • GC15645 structure
    GC15645Compound W
    CAS: 173550-33-9

    A Notch1 signaling modulator

  • GC13099 structure
    GC13099BMS 299897
    CAS: 290315-45-6
    纯度: >98.50%

    A γ-secretase inhibitor