P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC16259 SKF 525A (hydrochloride)
盐酸丙基解痉素,RP 5171|U 5446
A nonspecific CYP450 inhibitor
GC11155 Omeprazole sulfone
奥美拉唑杂质A,Omeprazole sulfone; Omeprazole sulphone
The major metabolite of omeprazole
GC14486 (S)-Mephenytoin
甲秦皮素,(S)-5-Ethyl-3-methyl-5-phenylhydantoin
S-Mephenytoin (5-phenyl-5-ethyl-N-methylhydantoin) 是一种抗惊厥药，通过 N-去甲基化和 4-羟基化（芳环）代谢。
GC16550 Diosmetin
香叶木素
A flavonoid with diverse biological activities
GC16951 Stiripentol
斯利潘托,BCX2600
An antiepileptic compound
GC16707 Isavuconazole
艾沙康唑; BAL-4815; RO-0094815
A broad-spectrum triazole antifungal agent
GC15445 TMS
2,3',4,5'-四甲氧基二苯乙烯,(E)-2,3',4,5'-tetramethoxystilbene
TMS（2,3',4,5'-tetramethoxystilbene）是一种特异性强效的CYP1B1抑制剂，IC₅₀值为6±2nmol/L。
GC14781 1-Aminobenzotriazole (ABT)
1-氨基苯并三唑,ABT; 3-Aminobenzotriazole
1-Aminobenzotriazole (ABT)是具有口服活性的细胞色素P450（CYP）的非特异性和不可逆抑制剂。
GC17411 Metyrapone
美替拉酮; Su-4885
Metyrapone是一种强效的口服11β羟化酶抑制剂和自噬激活剂，还能抑制醛固酮的产生。Metyrapone可用于抑郁症、动脉粥样硬化和癌症的研究。
GC16751 Chlorzoxazone
氯唑沙宗
A centrally acting muscle relaxant
GC14915 Gemfibrozil
吉非罗齐; CI-719
A PPARα and PPARγ agonist
GC12404 (+)-Ketoconazole
酮康唑
A triazole antifungal agent
GC12250 Fenofibrate
非诺贝特
A PPARα agonist
GC10198 Memantine hydrochloride
盐酸美金刚; D-145 hydrochloride
Memantine hydrochloride是一种非竞争性N-甲基-D-天冬氨酸受体（NMDAR）拮抗剂，IC₅₀值为0.5-1μM。
GC13362 TOK-001
TOK-001; VN-124-1
A CYP17 inhibitor
GC16256 BVT 948
4-羟基-3,3-二甲基-2H-苯并[G]吲哚-2,5(3H)-二酮
An inhibitor of protein tyrosine phosphatases
GC17063 Talarozole
他拉罗唑; R115866
Talarozole (R115866) 是一种口服全身性全反式维甲酸代谢阻断剂 (RAMBA)，可增加内源性全反式维甲酸 (RA) 的细胞内水平。
GC11170 Choline Fenofibrate
非诺贝特胆碱; ABT-335
非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐，可在胃肠道中释放游离的非诺贝酸。
GC16754 Clarithromycin
克拉霉素
Clarithromycin是一种大环内酯类抗生素，通过抑制细菌蛋白质合成发挥作用，与细菌核糖体的50S亚基结合，阻止肽链延长，从而抑制细菌生长。
GC10999 Avasimibe
阿伐麦布,CI-1011; PD-148515
Avasimibe是一种选择性口服酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂（IC₅₀=12μmol/L）。
GC17337 Ketoconazole
酮康唑
A triazole antifungal agent
GC14269 Cobicistat (GS-9350)
可比司他,GS-9350
An inhibitor of CYP3A
GC12280 PF-4981517
CYP3cide,PF-04981517,PF4981517
A potent, selective inhibitor of CYP3A4
GC16575 Alizarin
1,2-二羟基蒽醌
A CYP450 inhibitor
GC17645 Abiraterone
阿比特龙,CB 7598,16-dien-3-ol,CB7598
Abiraterone是一种FDA批准的CYP17A1抑制剂，已获批准用于去势抵抗性前列腺癌（CRPC）的治疗。
GC11108 Abiraterone acetate
乙酸阿比特龙酯,CB7630
A CYP17A1 inhibitor
GC10240 Atazanavir sulfate (BMS-232632-05)
硫酸阿扎那韦; BMS-232632 sulfate
An inhibitor of HIV-1 protease
GC12945 Atazanavir
阿扎那韦; BMS-232632

An inhibitor of HIV-1 protease
GN10257 Naringin
柚皮苷; Naringoside
A natural flavanone glycoside
GN10568 Isosilybin
异水飞蓟宾,Isosilybinin
A flavanolignan with antioxidant and anticancer activities
GN10649 Polygalaxanthone III
远志山酮III
A xanthone glycoside with antioxidant activity
GN10200 Salvianolic acid C
丹酚酸 C
Salvianolic acid C 是一种非竞争性细胞色素 P4502C8 (CYP2C8) 抑制剂和细胞色素 P45022J2 (CYP2J2) 的中度混合抑制剂，对 CYP2C8 和 CYP2J2 的 Kis 分别为 4.82 μM 和 5.75 μM。
GN10137 Galangin
高良姜素; Norizalpinin; 3,5,7-Trihydroxyflavone
A natural flavonoid
GN10720 Gentiopicrin
龙胆苦苷; Gentiopicrin
An iridoid glycoside with diverse biological activities
GN10150 Apigenin
芹菜素; 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1
芹菜素(Apigenin,API)是一种竞争性 CYP2C9 抑制剂,Ki 为2 µM。.
GN10549 Ginsenoside Rd
人参皂苷 Rd; Gypenoside VIII
A natural steroid glycoside with diverse effects
GN10032 Ginsenoside F1
人参皂苷 F1; 20(S)-Ginsenoside F1
Ginsenoside F1是从人参中提取的次级代谢产物，是人参皂苷Rg1的脱糖衍生物。
GN10330 8-Methoxypsoralen
甲氧沙林; 8-Methoxypsoralen; Xanthotoxin; 8-MOP
8-Methoxypsoralen (8-Methoxypsoralen) 是一种有效的 CYP（细胞色素 P-450）三环呋喃香豆素自杀抑制剂，是一种用于治疗银屑病、湿疹、白癜风和一些皮肤淋巴瘤以及将皮肤暴露在阳光下的药物。
GN10241 5-Methoxypsoralen
佛手柑内酯; 5-Methoxypsoralen
A furanocoumarin derivative with diverse biological activities