GlpBio

Pim

Pim(皮姆)

Pim protein kinases are a family of serine/threonine kinases consisting of three members of Ca2+/calmodulin-dependent protein kinases, including PIM1, PIM2 and PIM3, that are responsible for cell cycle regulation and antiapoptotic activity as well as homing and migration of receptor tyrosine kinases mediated through the JAK/STAT pathway. All three pim protein kinases share high homology at the amino acid level and hence exhibit greatly overlapping functions, in which 71% and 61% identical amino acids have been found between PIM1/PIM3 and between PIM1/PIM2 respectively. PIM1 comprises two isoforms of 34 and 44 kDa respectively; while PIM2 comprises three isoforms of 34, 37 and 40 kDa respectively. However, PIM3 comprises only one protein.

Pim 相关产品(30)

  • GC65278 structure
    GC65278PIM1-IN-1
    CAS: 1417630-95-5
    纯度: >99.00%

    PIM1-IN-1 是一种有效、高度选择性的 PIM1/3 抑制剂，对 PIM1，PIM2 和 PIM3 的 IC50 值分别为 7，5530 和 70 nM。PIM1-IN-1 抑制 PIM 下游蛋白 BAD 的磷酸化，EC50 值为 262 nM，而对 FLT3 或 hERG 无作用。具有抗增殖、抗肿瘤作用。

  • GC72931 structure
    GC72931HTH-01-091 TFA
    纯度: >98.00%

    HTH-01-091 TFA是一种有效的、选择性的母胚亮氨酸拉链激酶（MELK）抑制剂，IC50为10.5 nM。

  • GC72990 structure
    GC72990HJ-PI01
    CAS: 6192-43-4
    纯度: >99.00%

    HJ-PI01（10-乙酰苯恶嗪）是一种口服活性的Pim-2抑制剂。

  • GC73729 structure
    GC73729IBL-302
    CAS: 1414455-21-2
    纯度: >98.00%

    IBL-302（AMU302）是一种口服的PIM和PI3K/AKT/mTOR双重信号抑制剂，具有抗乳腺癌症和神经母细胞瘤的活性。

  • GC73968 structure
    GC73968Pim-1 kinase inhibitor 8
    CAS: 916038-47-6
    纯度: >99.00%

    Pim-1 kinase inhibitor 8（化合物12）是一种有效的Pim-1激酶抑制剂，IC50为14.3 nM。

  • GC11990 structure
    GC11990TCS-PIM-1-4a
    CAS: 327033-36-3
    纯度: >99.50%

    TCS-PIM-1-4a (SMI-4a) 是一种泛 Pim 激酶抑制剂，通过激活 AMPK 来阻断 mTORC1 的活性。 TCS-PIM-1-4a 可杀死多种髓系和淋巴系细胞系（IC50 值范围为 0.8 μM 至 40 μM）。