GlpBio

Pim

Pim(皮姆)

Pim protein kinases are a family of serine/threonine kinases consisting of three members of Ca2+/calmodulin-dependent protein kinases, including PIM1, PIM2 and PIM3, that are responsible for cell cycle regulation and antiapoptotic activity as well as homing and migration of receptor tyrosine kinases mediated through the JAK/STAT pathway. All three pim protein kinases share high homology at the amino acid level and hence exhibit greatly overlapping functions, in which 71% and 61% identical amino acids have been found between PIM1/PIM3 and between PIM1/PIM2 respectively. PIM1 comprises two isoforms of 34 and 44 kDa respectively; while PIM2 comprises three isoforms of 34, 37 and 40 kDa respectively. However, PIM3 comprises only one protein.

Pim 相关产品(30)

  • GC12660 structure
    GC12660AZD1208
    CAS: 1204144-28-4
    纯度: >98.00%

    AZD1208 是一种有效、高选择性且可口服的 Pim 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 IC50 值分别为 0.4、5 和 1.9nM。

  • GC13056 structure
    GC13056CX-6258
    CAS: 1202916-90-2
    纯度: >99.50%

    A pan-Pim kinase inhibitor

  • GC13154 structure
    GC13154Pim1/AKK1-IN-1
    CAS: 1093222-27-5
    纯度: >98.00%

    Pim1/AKK1-IN-1是一种有效的多靶点抑制剂，对Pim1、AKK1（AAK1）、LKB1和MST2等激酶具有抑制作用。

  • GC13488 structure
    GC13488R8-T198wt
    CAS: 2305815-72-7

    R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。

  • GC13558 structure
    GC13558PIM-1 Inhibitor 2
    CAS: 477845-12-8

    A potent PIM-1 kinase inhibitor

  • GC16497 structure
    GC16497SGI-1776 free base
    CAS: 1025065-69-3
    纯度: >99.00%

    SGI-1776 free base是一种ATP竞争性的Pim激酶抑制剂，可抑制Pim-1（IC 50 =7nM）、Pim-2（IC 50 =363nM）和Pim-3（IC 50 =69nM）的活性。

  • GC17178 structure
    GC17178TCS PIM-1 1
    CAS: 491871-58-0
    纯度: >98.00%

    A Pim-1 kinase inhibitor

  • GC11104 structure
    GC11104SMI-4a
    CAS: 438190-29-5
    纯度: >99.50%

    A Pim kinase inhibitor

  • GC12359 structure
    GC12359Hispidulin
    CAS: 1447-88-7
    纯度: >99.00%

    A flavonoid with diverse biological activities

  • GC19361 structure
    GC19361TP-3654
    CAS: 1361951-15-6
    纯度: >99.50%

    A Pim kinase inhibitor

  • GC19398 structure
    GC19398PIM447
    CAS: 1210608-43-7

    PIM447 (LGH447) 是一种有效的、口服的、选择性的泛 PIM 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 Ki 值分别为 6、18 和 9 pM。 PIM447 具有双重抗骨髓瘤和骨保护作用。 PIM447 诱导细胞凋亡。

  • GC19419 structure
    GC19419PIM inhibitor 1 phosphate
    CAS: 2088852-47-3
    纯度: >98.00%

    Uzansertib (INCB053914) phosphate 是一种具有口服活性的 ATP 竞争性泛 PIM 激酶抑制剂，对 PIM1、PIM2、PIM3 的 IC50 分别为 0.24 nM、30 nM、0.12 nM。 PIM inhibitor 1 phosphate 对多种血液肿瘤细胞系具有广泛的抗增殖活性。

  • GC19747 structure
    GC19747CX-6258 HCl
    CAS: 1353859-00-3
    纯度: >99.00%

    A pan-Pim kinase inhibitor

  • GC32958 structure
    GC32958GDC-0339
    CAS: 1428569-85-0
    纯度: >99.50%

    GDC-0339是Pim激酶抑制剂,作用于BaF3PIM1时,IC50为43.6nM。

  • GC33253 structure
    GC33253GNE-955
    CAS: 1527523-39-2

    GNE-955是有效的泛Pim激酶抑制剂，Ki分别为18，110，8nM。

  • GC34138 structure
    GC34138M-110
    CAS: 1395048-49-3
    纯度: >98.50%

    M-110是Pim激酶抑制剂，抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。

  • GC34964 structure
    GC34964(1S,3R,5R)-PIM447 dihydrochloride
    纯度: >98.00%

    (1S,3R,5R)-PIM447 (dihydrochloride)是PIM的抑制剂，来自专利US 20100056576 A1化合物实例72。对Pim1，Pim2和Pim3的IC50分别为0.095，0.522和0.369 μM。

  • GC35447 structure
    GC35447AZD1208 hydrochloride
    CAS: 1621866-96-3

    A pan-Pim kinase inhibitor

  • GC35762 structure
    GC35762CX-6258 hydrochloride hydrate
    CAS: 1353858-99-7
    纯度: >98.50%

    A pan-Pim kinase inhibitor

  • GC36918 structure
    GC36918PIM-447 dihydrochloride
    CAS: 1820565-69-2
    纯度: >99.00%

    PIM447是泛PIM激酶抑制剂，对PIM1，PIM2，PIM3的 Ki 分别为6，18，9 nM。

  • GC37651 structure
    GC37651SMI-16a
    CAS: 587852-28-6
    纯度: >99.50%

    A Pim-1 kinase inhibitor

  • GC39485 structure
    GC39485CK2/ERK8-IN-1
    CAS: 1085822-09-8
    纯度: >99.00%

    A dual inhibitor of CK2 and ERK8

  • GC64774 structure
    GC64774SEL24-B489
    CAS: 1616359-00-2
    纯度: >98.00%

    SEL24-B489 是有效的、I 型的、口服有效的、PIM 和 FLT3-ITD 的双抑制剂，其对PIM1、PIM2 和 PIM3 的 Kd 值分别为 2 nM、2 nM、和 3 nM。

  • GC65201 structure
    GC65201Quercetagetin
    CAS: 90-18-6
    纯度: >99.00%

    A selective Pim-1 inhibitor