Apoptosis
Apoptosis(凋亡)
FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.
FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.
Apoptosis 相关产品(777)
- GC52104Ponatinib (hydrochloride)CAS: 1114544-31-8纯度: >98.00%
Ponatinib (hydrochloride)是一种多靶点酪氨酸激酶抑制剂，可抑制Abl（IC 50 =0.37nM），PDGFRα（IC 50 =1.1nM），VEGFR2（IC 50 =1.5nM），FGFR1（IC 50 =2.2nM）和Src（IC 50 =5.4nM）的活性。
- GC52192(S)-4'-nitro-BlebbistatinCAS: 1621326-32-6纯度: >99.50%
A more stable and less phototoxic form of (–)-blebbistatin
- GC522275-(3',4'-Dihydroxyphenyl)-γ-ValerolactoneCAS: 21618-92-8纯度: >95.00%
An active metabolite of various polyphenols
- GC52269Cinnabarinic Acid-d4纯度: >99.00%
An internal standard for the quantification of cinnabarinic acid
- GC52288Fumonisin B1-13C34CAS: 1217458-62-2纯度: >95.00%
An internal standard for the quantification of fumonisin B 1
- GC52318Oleic Acid-13C5CAS: 1255644-48-4纯度: >95.00%
An internal standard for the quantification of oleic acid
- GC52367Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide纯度: >99.00%
A biotinylated and citrullinated mutant vimentin peptide
- GC52370Citrullinated Vimentin (R144) (139-159)-biotin Peptide纯度: >98.00%
A biotinylated and citrullinated vimentin peptide
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC50045 | PD 166285 dihydrochloride | 212391-63-4 | - | |
A tyrosine kinase inhibitor | ||||
| GC50109 | AZD 5582 dihydrochloride | 1883545-51-4 | >97.00% | |
A Smac mimetic and IAP inhibitor | ||||
| GC50190 | Fenretinide - d4 | 2118244-64-5 | - | |
An internal standard for the quantification of fenretinide | ||||
| GC50253 | PF 543 hydrochloride | 1706522-79-3 | >98.00% | |
A potent inhibitor of SPHK1 | ||||
| GC50280 | JX 06 | 729-46-4 | >99.50% | |
An irreversible PDHK inhibitor | ||||
| GC50296 | D9 | 1527513-89-8 | - | |
D9 是一种有效的选择性硫氧还蛋白还原酶 (TrxR) 抑制剂，EC50 为 2.8 nM。 D9 具有在体外和体内抑制肿瘤增殖的能力。 | ||||
| GC52104 | Ponatinib (hydrochloride) | 1114544-31-8 | >98.00% | |
Ponatinib (hydrochloride)是一种多靶点酪氨酸激酶抑制剂，可抑制Abl（IC 50 =0.37nM），PDGFRα（IC 50 =1.1nM），VEGFR2（IC 50 =1.5nM），FGFR1（IC 50 =2.2nM）和Src（IC 50 =5.4nM）的活性。 | ||||
| GC52115 | S-99 | 1124381-69-6 | >98.00% | |
An inhibitor of ASK1 | ||||
| GC52192 | (S)-4'-nitro-Blebbistatin | 1621326-32-6 | >99.50% | |
A more stable and less phototoxic form of (–)-blebbistatin | ||||
| GC52196 | RGD Peptide | 114681-65-1 | >98.00% | |
An inhibitor of integrin-ligand interactions | ||||
| GC52227 | 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone | 21618-92-8 | >95.00% | |
An active metabolite of various polyphenols | ||||
| GC52245 | CAY10792 | 2361009-68-7 | >98.00% | |
An anticancer agent | ||||
| GC52269 | Cinnabarinic Acid-d4 | - | >99.00% | |
An internal standard for the quantification of cinnabarinic acid | ||||
| GC52288 | Fumonisin B1-13C34 | 1217458-62-2 | >95.00% | |
An internal standard for the quantification of fumonisin B 1 | ||||
| GC52293 | STAT3 Inhibitor 4m | - | >98.00% | |
A STAT3 inhibitor | ||||
| GC52318 | Oleic Acid-13C5 | 1255644-48-4 | >95.00% | |
An internal standard for the quantification of oleic acid | ||||
| GC52344 | Bak BH3 (72-87) (human) (trifluoroacetate salt) | - | >95.00% | |
A Bak-derived peptide | ||||
| GC52355 | BimS BH3 (51-76) (human) (trifluoroacetate salt) | - | >95.00% | |
A Bim-derived peptide | ||||
| GC52364 | Vimentin (139-159)-biotin Peptide | - | >98.00% | |
A biotinylated vimentin peptide | ||||
| GC52367 | Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide | - | >99.00% | |
A biotinylated and citrullinated mutant vimentin peptide | ||||
| GC52370 | Citrullinated Vimentin (R144) (139-159)-biotin Peptide | - | >98.00% | |
A biotinylated and citrullinated vimentin peptide | ||||
| GC52371 | Vimentin (G146R) (139-159)-biotin Peptide | - | >98.00% | |
A biotinylated mutant vimentin peptide | ||||
| GC52372 | Ac-VDVAD-AFC (trifluoroacetate salt) | - | >95.00% | |
A fluorogenic substrate for caspase-2 | ||||
| GC52472 | Inostamycin A (sodium salt) | - | >85.00% | |
A bacterial metabolite with anticancer activity | ||||