GlpBio

Bak BH3 (72-87) (human) (trifluoroacetate salt)

目录号: GC52344纯度: >95.00%
A Bak-derived peptide
Bak BH3 (72-87) (human) (trifluoroacetate salt)
规格价格库存数量操作
5 mg¥756.00现货
1
10 mg¥1,442.00现货
1
25 mg¥3,416.00现货
1
50 mg¥6,048.00现货
1
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文献被引

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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Bak BH3 (72-87) is a peptide that corresponds to amino acids 72-87 of the pro-apoptotic protein Bak.1 It selectively binds to Bcl-xL over Bcl-2 (EC50s = 174 and 3,020 nM, respectively). Bak BH3 (72-87) induces apoptosis in LLC-PK1 porcine kidney epithelial cells.2

1.Frey, V., Viaud, J., Subra, G., et al.Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacementEur. J. Med. Chem.43(5)966-972(2008) 2.Peherstorfer, E., Mayer, B., Boehm, S., et al.Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cellsAm. J. Physiol. Renal. Physiol.283(1)F190-F196(2002)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

SMILES
N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式
C72H125N25O24 ? XCF3COOH
分子量
1724.9 g/mol
溶解性
DMF: insol,DMSO: 10 mg/ml,Ethanol: insol,PBS (pH 7.2): 3 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol