GlpBio

Apoptosis Inducers

Apoptosis Inducers(细胞凋亡诱导剂)

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Apoptosis Inducers 相关产品(43)

  • GC11834 structure
    GC11834Epibrassinolide
    CAS: 78821-43-9
    纯度: >98.00%

    Epibrassinolide是一种广泛存在的油菜素类固醇植物生长激素。

  • GC12649 structure
    GC12649TW-37
    CAS: 877877-35-5
    纯度: >99.00%

    An inhibitor of the Bcl-2 family proteins

  • GC16116 structure
    GC16116Costunolide
    CAS: 553-21-9
    纯度: >99.00% / >98.00%

    A natural sesquiterpene lactone

  • GC10480 structure
    GC10480Betulinic acid
    CAS: 472-15-1
    纯度: >98.00%

    白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC 50 值为5μM。

  • GC10661 structure
    GC10661Destruxin B
    CAS: 2503-26-6

    An insecticidal mycotoxin

  • GC10744 structure
    GC10744Bendamustine HCl
    CAS: 3543-75-7
    纯度: >98.50%

    A DNA alkylating agent

  • GC11710 structure
    GC11710CFM 4
    CAS: 331458-02-7

    CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合，导致 G2M 细胞周期停滞，并诱导细胞凋亡，IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。

  • GC11988 structure
    GC1198815-acetoxy Scirpenol
    CAS: 2623-22-5

    A trichothecene mycotoxin

  • GC12053 structure
    GC12053BAM7
    CAS: 331244-89-4
    纯度: >99.00%

    A direct activator of Bax

  • GC12139 structure
    GC12139Gambogic Acid
    CAS: 2752-65-0

    Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。

  • GC12353 structure
    GC12353Mitomycin C
    CAS: 50-07-7
    纯度: >98.00%

    Mitomycin C是一种抗生素，从链霉菌（Streptomyces Caespitosus）或淡紫色链霉菌（Streptomyces Lavendulae）中分离出来。

  • GC12961 structure
    GC12961Apicidin
    CAS: 183506-66-3
    纯度: >98.00% / >90.00%

    A cell-permeable HDAC inhibitor

  • GC13034 structure
    GC13034ML-291
    CAS: 1523437-16-2

    An activator of apoptosis through UPR

  • GC14050 structure
    GC14050MPI-0441138
    CAS: 827030-33-1

    A potent inducer of apoptosis and growth inhibition

  • GC14791 structure
    GC14791F16
    CAS: 36098-33-6
    纯度: >98.00%

    A potential antitumor agent

  • GC14847 structure
    GC14847Psoralidin
    CAS: 18642-23-4
    纯度: >98.00%

    A furanocoumarin with anti-cancer activity

  • GC15084 structure
    GC150842-Methoxyestradiol (2-MeOE2)
    CAS: 362-07-2
    纯度: >99.50% / >98.00%

    2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。

  • GC15503 structure
    GC15503NSC 687852 (b-AP15)
    CAS: 1009817-63-3
    纯度: >98.50%

    An inhibitor of the deubiquitinases USP14 and UCHL5

  • GC16037 structure
    GC160377BIO
    CAS: 916440-85-2

    A caspase-independent (nonapoptotic) cell death inducer

  • GC16375 structure
    GC16375(±)-Jasmonic Acid methyl ester
    CAS: 39924-52-2
    纯度: >98.00%

    (±)-Jasmonic Acid methyl ester是一种重要的天然植物信号分子和植物激素，具备多种生物学活性。

  • GC16661 structure
    GC16661Citrinin
    CAS: 518-75-2
    纯度: >98.00%

    Citrinin是一种具有多种生物活性的霉菌毒素，由青霉属、曲霉属和红曲霉属的几种真菌菌株产生。

  • GC17198 structure
    GC17198Cycloheximide
    CAS: 66-81-9
    纯度: >98.00%

    环己酰亚胺是一种抗生素，它在翻译水平上抑制蛋白质合成，仅对真核细胞的细胞质（80s）核糖体起作用。

  • GN10421 structure
    GN10421Kaempferol
    CAS: 520-18-3
    纯度: >99.50% / >98.00% / >97.00% / >98.50%

    Kaempferol是一种黄酮类化合物，可作为ERRα和ERRγ的反向激动剂，具有抗氧化、抗炎和抗肿瘤活性。

  • GC12791 structure
    GC127913,3'-Diindolylmethane
    CAS: 1968-05-4
    纯度: >98.00%

    A phytochemical with antiradiation and chemopreventative effects