GlpBio

(Rac)-Tavapadon

目录号: GC60003纯度: >99.50%同义词: (Rac)-PF-06649751; (Rac)-CVL-751
(Rac)-Tavapadon((Rac)-PF-06649751;(Rac)-CVL-751)是有效的，选择性非儿茶酚多巴胺D1受体(dopamineD1receptor)激动剂。(Rac)-Tavapadon在GS激活试验中显示出强大的完全激动作用，在β-arrestin2募集试验中显示出部分激动作用(GS-cAMP,EC50=0.8nM;β-arrestin2,EC50=68nM)。(Rac)-Tavapadon具有抗帕金森病活性。
(Rac)-Tavapadon
Cas No.: 1643462-64-9
规格价格库存数量操作
5mg¥1,215.00现货
1
10mg¥1,980.00现货
1
50mg¥5,400.00现货
1
10mM (in 1mL DMSO)¥1,337.00现货
1
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文献被引

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产品描述 Description

(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC50=0.8 nM; β-arrestin2, EC50=68 nM). (Rac)-Tavapadon has antiparkinsonian activity[1].

(Rac)-Tavapadon ((Rac)-PF-06649751; (Rac)-CVL-751; compound 32) has EMAXs of 118% and 30% in the GS activation assay and the β-arrestin2 recruitment assay[1].

[1]. Michael L Martini, et al. Designing Functionally Selective Noncatechol Dopamine D 1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. ACS Chem Neurosci. 2019 Sep 18;10(9):4160-4182.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1643462-64-9
同义词
(Rac)-PF-06649751; (Rac)-CVL-751
SMILES
O=C1NC(C(C)=C(C2=CC=C(OC3=NC=CC=C3C(F)(F)F)C=C2C)N1C)=O
分子式
C19H16F3N3O3
分子量
391.34 g/mol
溶解性
DMSO: 41.67 mg/mL (106.48 mM); Water: < 0.1 mg/mL (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol