PROTAC TYK2 degradation agent1 is a potent and subtype-selective TYK2 degrader. PROTAC TYK2 degradation agent1 has TYK2 degradation activity with DC50 value of 14 nM. PROTAC TYK2 degradation agent1 can be used for the research of autoimmune disease.
PROTAC TYK2 degradation agent1 (degrader 37) (1 µM; 6 h) selectively suppresses TYK2 protein levels[1].
PROTAC TYK2 degradation agent1 has TYK2 degradation activity with DC50 value of 14 nM[1].
References:
[1]. Jun-Ya Kato, et al. Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor. Bioorg Med Chem Lett. 2023 Jan 1;79:129083.