GlpBio

PROTAC KRAS G12C degrader-2

目录号: GC73493纯度: >98.00%
PROTAC KRAS G12C degrader-2（化合物432）是K-Ras蛋白水解的调节剂。
PROTAC KRAS G12C degrader-2
Cas No.: 2378257-72-6
规格价格库存数量操作
1 mg¥4,932.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein drolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.

References:
[1]. Crew Andrew, et al. Preparation of bifunctional compounds as modulators of proteolysis useful for treating cancer. World Intellectual Property Organization, WO2019195609 A2. 2019-10-10.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2378257-72-6
分子式
C51H53ClFN9O7
分子量
958.47 g/mol
溶解性
DMSO : 50 mg/mL (52.17 mM; Need ultrasonic)
保存条件
4°C, protect from light, stored under nitrogen
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol