Procyanidin B2 (PB2), an antioxidant from the proanthocyanidin flavonoid polyphenol group, is found in plants like grape seeds, berries, cocoa, and tea, offering pharmacological benefits including anti-oxidative and anti-inflammatory effects [1-3].
Procyanidin B2, when administered at concentrations ranging from 0 to 10 μM for 24 h, suppresses the secretion of sFlt-1 from primary placental tissues andendothelial cells [4]. Additionally, at concentrations of 1 to 2.5 μM, Procyanidin B2 enhances the angiogenic function, survival, and migration of Endothelial Progenitor Cells (EPCs) exposed to high glucose (HG) conditions [5].
Procyanidin B2 (PB2), administered intravenously at doses of 0.5, 1, or 2 mg/kg, contributes to the treatment of sepsis-induced Acute Lung Injury (ALI) by regulating cytokine storms and mitigating inflammation through modulation of the TLR4/NF-κB, PI3K/Akt, Hippo, and Rho signaling pathways [6]. Furthermore, Procyanidin B2 (50 mg/kg/day) administered orally for 6 weeks attenuates liver injury and hepatocyte pyroptosis in mice exposed to nicotine [7].
References:
[1]. Chen J, Zhong K, et,al. Procyanidin B2: A promising multi-functional food-derived pigment for human diseases. Food Chem. 2023 Sep 15;420:136101. doi: 10.1016/j.foodchem.2023.136101. Epub 2023 Apr 7. Erratum in: Food Chem. 2024 Feb 1;433:137359. PMID: 37059021.
[2]. Zhang JQ, Gao BW, et,al. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. Oxid Med Cell Longev. 2016;2016:6147345. doi: 10.1155/2016/6147345. Epub 2016 Jan 19. PMID: 27057282; PMCID: PMC4745910.
[3]. Kopustinskiene DM, Savickas A, et,al. Direct effects of (-)-epicatechin and procyanidin B2 on the respiration of rat heart mitochondria. Biomed Res Int. 2015;2015:232836. doi: 10.1155/2015/232836. Epub 2015 Feb 24. PMID: 25811024; PMCID: PMC4354975.
[4]. Liu L, Wang R, et,al. Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia. Pharmacol Res. 2022 Mar;177:106127. doi: 10.1016/j.phrs.2022.106127. Epub 2022 Feb 10. PMID: 35150862.
[5]. Fan J, Liu H, et,al. Procyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2. J Cell Mol Med. 2021 Jan;25(2):652-665. doi: 10.1111/jcmm.16111. Epub 2020 Nov 20. PMID: 33215883; PMCID: PMC7812287.
[6]. Kim GO, Park DH, et,al. Procyanidin B2 Attenuates Sepsis-Induced Acute Lung Injury via Regulating Hippo/Rho/PI3K/NF-κB Signaling Pathway. Int J Mol Sci. 2023 Apr 27;24(9):7930. doi: 10.3390/ijms24097930. PMID: 37175637; PMCID: PMC10177954.
[7]. Liu J, Yao Q, et,al. Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism. Nutrients. 2022 Apr22;14(9):1756. doi: 10.3390/nu14091756. PMID: 35565726; PMCID: PMC9103831.
Procyanidin B2 (PB2)是一种来自原花青素类黄酮多酚组的抗氧化剂，存在于葡萄籽、浆果、可可和茶等植物中，具有抗氧化和抗炎作用[1-3]。
Procyanidin B2在0 ~ 10 μM浓度范围内作用24小时，可抑制原代胎盘组织和内皮细胞分泌sFlt-1[4]。此外，在1 ~ 2.5 μM浓度下，Procyanidin B2可增强暴露于高糖(HG)条件下内皮祖细胞(EPCs)的血管生成功能、存活和迁移[5]。
Procyanidin B2 (PB2)以0.5-2 mg/kg的剂量静脉注射，通过调节TLR4/NF-κB、PI3K/Akt、Hippo和Rho信号通路，调节细胞因子风暴和减轻炎症，有助于治疗小鼠败血症诱导的急性肺损伤(ALI)[6]。此外，Procyanidin B2 (50 mg/kg/day)口服6周可减轻尼古丁暴露造成的小鼠肝损伤和肝细胞焦亡[7]。