GlpBio

Polyphyllin A

目录号: GN10709纯度: >98.00%同义词: 重楼皂苷I
A steroid saponin with anticancer activity
Polyphyllin A
Cas No.: 50773-41-6
规格价格库存数量操作
20mg¥1,620.00现货
1
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产品描述 Description

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

References:
[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.
[2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.
[3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
50773-41-6
同义词
重楼皂苷I
化学名
Chonglou saponin I
SMILES
O[C@@H]1[C@@H](O)[C@H](CO)O[C@@]1([H])O[C@H]2[C@H](O)[C@@H](O[C@@]3([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(O[C@H]4CC5=CC[C@]([C@@](C[C@@]6([H])[C@]7([H])[C@H](C)[C@]8(OC[C@H](C)CC8)O6)([H])[C@]7(C)CC9)([H])[C@@]9([H])[C@@]5(C)CC4)O[C@@H]2CO
分子式
C44H70O16
分子量
855.02 g/mol
溶解性
≥ 42.75mg/mL in EtOH with ultrasonic and warming
保存条件
Store at -20°C,protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol