Cyproconazole is a triazole fungicide.1 It reduces mycelial growth of A. mellea on grapevine roots. Cyproconazole also reduces defoliation of rose plants induced by the plant pathogenic fungus D. rosae.2 It is lethal to the freshwater invertebrates C. riparius and D. tigrina (LC50s = 17.46 and 47.38 mg/L, respectively, in tank water).3 Cyproconazole induces liver hypertrophy and fat vacuolation, as well as induces hepatocellular adenoma and carcinoma formation, in mice.4
1.Aguín, O., Mansilla, J.P., and Sainz, M.J.In vitro selection of an effective fungicide against Armillaria mellea and control of white root rot of grapevine in the fieldPest. Manag. Sci.62(3)223-228(2006) 2.Bowen, K.L., and Roark, R.S.Management of black spot of rose with winter fungicide treatmentPlant Dis.85(4)393-398(2001) 3.Saraiva, A.S., Sarmento, R.A., Golovko, O., et al.Lethal and sub-lethal effects of cyproconazole on freshwater organisms: A case study with Chironomus riparius and Dugesia tigrinaEnviron. Sci. Pollut. Res. Int.25(12)12169-12176(2018) 4.Peffer, R.C., Moggs, J.G., Pastoor, T., et al.Mouse liver effects of cyproconazole, a triazole fungicide: Role of the constitutive androstane receptorToxicol. Sci.99(1)315-325(2007)