GlpBio

Pimethixene maleate

目录号: GC65296纯度: >99.00%同义词: 匹美噻吨马来酸盐; Pimetixene maleate
Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.
Pimethixene maleate
Cas No.: 13187-06-9
规格价格库存数量操作
10mg¥315.00现货
1
10mM (in 1mL DMSO)¥346.00现货
1
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产品描述 Description

Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.

Pimethixene shows the least potency against pancreatic cancer cell lines with an IC50 up to a millimolar concentration.[2]

[1] Beate Schmitz, et al. Eur J Pharmacol. 2015 Mar 15;751:73-80. [2] Chien W, et al. Mol Oncol. 2015 Apr;9(4):889-905.

实验参考方法 Experimental Reference Method

5-HT1AReceptor

7.63(pKi)

5-HT2AReceptor

10.22(pKi)

5-HT2BReceptor

10.44(pKi)

5-HT2CReceptor

8.42(pKi)

D2receptor

8.19(pKi)

DD4.4receptor

7.54(pKi)

M1receptor

8.61(pKi)

M2receptor

9.38(pKi)

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
13187-06-9
同义词
匹美噻吨马来酸盐; Pimetixene maleate
分子式
C23H23NO4S
分子量
409.5 g/mol
溶解性
DMSO : 100 mg/mL (244.20 mM; Need ultrasonic)
保存条件
4&#176;C, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol